Madonna junior quarterback Ross Comis ran for 135 yards and passed for 114 yards, leading his Blue Dons to a 60-14 victory at Cameron.
Comis was nearly flawless through the air, hitting 11 of his 15 pass attempts, including three touchdowns.
Elliott Nero scored two touchdowns, including an 85-yard punt return, and Garrett Hypes scored twice on a 26-yard touchdown reception and a 41-yard punt return.
The Blue Dons (3-1) host Bridgeport next Saturday night.
Cameron (2-3) visits Paden City (1-4) next Friday night.