The Magnolia Blue Eagles scored the final 35 points in pulling away from the River Pilots in a 48-14 win at Alumni Field in New Martinsville.
Magnolia quarterback Jacob Brill passed for 201 yards with three touchdowns.
Senior Kage Rohde racked up 73 yards, and scored two touchdowns. Eric Smith caught five passes for 104 yards and a touchdown.
River's Joe Flannery connected with Bailey Reusser for a touchdown, and Jordan Sapp ran for a five-yard score.
The Pilots drop to 0-4 on the season and will host Caldwell (2-2) next Friday night.
Magnolia, now 2-2, will visit Wheeling Central next Saturday night at Wheeling Island Stadium.